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Early satiety during meals is common
Interestingly, a meta-analysis of studies on overweight hypertensive individuals without diabetes reported that semaglutide treatment can lead to a significant reduction in blood pressure
Pre-Diabetes gone
Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
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